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himalayandude
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 Natural-born painkiller found in human saliva
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Posted on 11-14-06 9:30 AM     Reply [Subscribe]
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Saliva from humans has yielded a natural painkiller up to six times more powerful than morphine, researchers say.

The substance, dubbed opiorphin, may spawn a new generation of natural painkillers that relieve pain as well as morphine but without the addictive and psychological side effects of the traditional drug.

When the researchers injected a pain-inducing chemical into rats’ paws, 1 gram of opiorphin per kilogram of body weight achieved the same painkilling effect as 3 grams of morphine.

The substance was so successful at blocking pain that, in a test involving a platform of upended pins, the rats needed six times as much morphine as opiorphin to render them oblivious to the pain of standing on the needle points.
Anti-depressive angle

“Its pain-suppressive effect is like that of morphine,” says Catherine Rougeot at the Pasteur Institute in Paris, France, who led the research. “But we have to test its side effects as it is not a pure painkiller,” she says. “It may also be an anti-depressive molecule.”

Rougeot and colleagues discovered that opiorphin works in nerve cells of the spine by stopping the usual destruction of natural pain-killing opiates there, called enkephalins.

Opiorphin is such a simple molecule that it should be possible to synthesise it and produce large quantities without having to isolate it from saliva, Rougeot explains. Alternatively, it might be possible to find drugs which trigger patients’ bodies to produce more of the molecule themselves.

Journal reference: Proceedings of the National Academy of Sciences (vol 103, p 17979)
 
Posted on 11-14-06 9:32 AM     Reply [Subscribe]
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Posted on 11-14-06 4:55 PM     Reply [Subscribe]
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One more reason to love french kiss...muah.
 
Posted on 11-14-06 5:25 PM     Reply [Subscribe]
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Hi himalayandude ,
Can you provide me the link to article or some way of getting the article? When I checked "Proceedings of the National Academy of Sciences vol 103", there is no page 17979.It seens to be the page number of future issue of the journal as present journal is only upto page17567.
Thanks
 
Posted on 11-14-06 8:36 PM     Reply [Subscribe]
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Naya gahre thuldai,

I got it at

Slashdot



Hope will help you
 
Posted on 11-15-06 12:50 AM     Reply [Subscribe]
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Looks like heroin addicts dont have to go and buy the expensive street drug.
 


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